Down-regulation of circulating microRNA let-7a in Egyptian smokers
نویسندگان
چکیده
منابع مشابه
MYC-Induced Growth in Burkitt Lymphoma Cells MicroRNA Let-7a Down-regulates MYC and Reverts
Regulation of the MYC oncogene remains unclear. Using 10058-F4, a compound that inhibits MYC-MAX transcription factor, MYC protein and gene expression were down-regulated in Namalwa cells, a Burkitt lymphoma. Compound 10058-F4 decreased MYC mRNA (45%), MYC protein (50%), and cell growth (32%). MYC-MAX transcription factor was disrupted 24 h after treatment, resulting in transcriptional inhibiti...
متن کاملMicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells.
Regulation of the MYC oncogene remains unclear. Using 10058-F4, a compound that inhibits MYC-MAX transcription factor, MYC protein and gene expression were down-regulated in Namalwa cells, a Burkitt lymphoma. Compound 10058-F4 decreased MYC mRNA (45%), MYC protein (50%), and cell growth (32%). MYC-MAX transcription factor was disrupted 24 h after treatment, resulting in transcriptional inhibiti...
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Microglia have multiple functions in cerebrovascular and neurodegenerative diseases. Regulation of microglial function during inflammatory stress is important for treatment of central nervous system (CNS) diseases because microglia secrete various substances that affect neurons and glia. MicroRNA-Let-7a (miR-Let-7a) is a tumor suppressor miRNA that has been reported to target transcripts that e...
متن کاملMicroRNA let-7a: a novel therapeutic candidate in prostate cancer
The above‑described results demonstrate a genetic association between let‑7a and PCa, supporting a potential role for let‑7a in human PCa. A recent study showed that let‑7a remained to significantly discriminate normal tissues from PCa patients from those of the cancer negative control group with elevated prostate‑specific antigen levels (P < 0.05). 8 In any case, reduced transcription patterns...
متن کاملArgonaute-3 activates the let-7a passenger strand microRNA
MicroRNA duplices are separated into a guide and a passenger strand. By convention, the guide represents the active microRNA while the passenger is supposedly degraded. However, passenger strands also emerge as active microRNAs. It is unknown whether the guide-to-passenger-strand ratio can be actively regulated and which factors influence strand incorporation into the RISC. Here, we identify a ...
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ژورنال
عنوان ژورنال: Journal of Genetic Engineering and Biotechnology
سال: 2018
ISSN: 1687-157X
DOI: 10.1016/j.jgeb.2018.02.003